No, Radhe Shyam is not based on any true incident or historical event. Radhe Shyam is a 2022 Indian period romantic drama fantasy movie written and directed by Radha Krishna Kumar. The movie was shot simultaneously in Telugu and Hindi languages. Produced by UV Creations and T-Series, Radhe Shyam stars Prabhas and Pooja Hegde in lead roles, with an ensemble of supporting cast, including Bhagyashree, Sathyaraj and Krishnam Raju.
Radhe Shyam is a romantic fantasy, scripted for entertainment. However, the movie takes partial inspiration from palmistry, the ancient art of predicting the future by reading the palms. The protagonist of the movie is modelled after Cheiro, a famous Irish astrologer and palmist from the late 19th to early 20th century.

Plot Summary
Radhe Shyam is set in 1970s, primarily in Europe. Vikramaditya is a brilliant and a renowned palmist who has an uncanny accuracy in reading palms and predicting future events. However, his own palm reading reveals that he is not destined to fall in love or marry. While in Italy, Vikramaditya meets Prerna, a young doctor. While Prerna believes in science over fate, Vikramaditya believes everything is written in the stars.
Despite holding opposing views, Vikramaditya and Prerna fall in love. Their love blossoms amidst picturesque European locations. Vikramaditya predicts a long and happy life for Prerna. However, tragedy strikes and Prerna is diagnosed with a terminal illness, contradicting Vikramaditya’s prediction and shaking his belief in palmistry. Another palmist predicts a tragic future for Vikramaditya himself.
As destiny pulls Vikramaditya and Prerna away from each other, Vikramaditya struggles to beat fate with willpower and love. The film builds to a dramatic climax involving a massive disaster, where love triumphs over destiny.
Real World Inspirations
Radhe Shyam uses the traditional practice of palmistry and astrology as a symbolic element. Palmistry serves as the backdrop to help the movie in exploring the question of how much of life is predetermined as opposed to individual choices. In pre-release interviews, director Radha Krishna Kumar mentioned his researches into palmistry for the plot.
Vikramaditya’s character mirrors William John Werner, popularly known as Cheiro. Cheiro was an Irish astrologer who learned astrology in India in the 1880s. He was an expert in palmistry and numerology, and known for accurately predicting many world events.